<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:cd578b04-11b9-41e7-95eb-53f4b9e0acc8,g:ca43dcc2-44ed-4933-94f5-373d0d4bde67-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.biontech.de/role/ConsolidatedStatementsofProfitorLoss" xlink:type="simple" xlink:href="bntx-20211231.xsd#ConsolidatedStatementsofProfitorLoss"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ConsolidatedStatementsofProfitorLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_81dab4f8-3a63-44d9-b05f-65bbb9c98b41" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_5012e7ad-2ce4-4225-9bae-bbeecb469d84" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_81dab4f8-3a63-44d9-b05f-65bbb9c98b41" xlink:to="loc_ifrs-full_ProfitLossFromOperatingActivities_5012e7ad-2ce4-4225-9bae-bbeecb469d84" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_5ffab2f3-fbf0-4fff-88da-c8bfbe8e889d" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinanceCosts"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_81dab4f8-3a63-44d9-b05f-65bbb9c98b41" xlink:to="loc_ifrs-full_FinanceCosts_5ffab2f3-fbf0-4fff-88da-c8bfbe8e889d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_4b0a68d5-6393-4472-bbf8-f4a75b1a8e17" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinanceIncome"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_81dab4f8-3a63-44d9-b05f-65bbb9c98b41" xlink:to="loc_ifrs-full_FinanceIncome_4b0a68d5-6393-4472-bbf8-f4a75b1a8e17" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_e8a34125-4207-4d95-81bb-801ddbda8195" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_4c59fad1-e410-4e15-92c4-f590d1cc786d" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossAttributableToOwnersOfParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_e8a34125-4207-4d95-81bb-801ddbda8195" xlink:to="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_4c59fad1-e410-4e15-92c4-f590d1cc786d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToNoncontrollingInterests_bafdf779-0e59-46ca-9975-38644870c947" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossAttributableToNoncontrollingInterests"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_e8a34125-4207-4d95-81bb-801ddbda8195" xlink:to="loc_ifrs-full_ProfitLossAttributableToNoncontrollingInterests_bafdf779-0e59-46ca-9975-38644870c947" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_fd626572-4e71-4307-b7d8-4a0d2b97bea0" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromContractsWithCustomers_855137db-6eaf-49c8-b4ca-a72d698e5461" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RevenueFromContractsWithCustomers"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_fd626572-4e71-4307-b7d8-4a0d2b97bea0" xlink:to="loc_ifrs-full_RevenueFromContractsWithCustomers_855137db-6eaf-49c8-b4ca-a72d698e5461" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ResearchAndDevelopmentExpense_e99c3434-8503-4c8f-9ac4-d4e59c532d42" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_fd626572-4e71-4307-b7d8-4a0d2b97bea0" xlink:to="loc_ifrs-full_ResearchAndDevelopmentExpense_e99c3434-8503-4c8f-9ac4-d4e59c532d42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SalesAndMarketingExpense_47dbc47c-9964-4d7d-90b4-5dbf5730f9b4" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SalesAndMarketingExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_fd626572-4e71-4307-b7d8-4a0d2b97bea0" xlink:to="loc_ifrs-full_SalesAndMarketingExpense_47dbc47c-9964-4d7d-90b4-5dbf5730f9b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MiscellaneousOtherOperatingExpense_fc6474c0-35c8-4f55-9b03-ec11043e1d6a" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_MiscellaneousOtherOperatingExpense"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_fd626572-4e71-4307-b7d8-4a0d2b97bea0" xlink:to="loc_ifrs-full_MiscellaneousOtherOperatingExpense_fc6474c0-35c8-4f55-9b03-ec11043e1d6a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GeneralAndAdministrativeExpense_35615ccd-6c1b-49fa-b1d1-1a0a741dbf77" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_fd626572-4e71-4307-b7d8-4a0d2b97bea0" xlink:to="loc_ifrs-full_GeneralAndAdministrativeExpense_35615ccd-6c1b-49fa-b1d1-1a0a741dbf77" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CostOfSales_217be760-6b5b-4fad-9007-ceebd93b5f0d" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CostOfSales"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_fd626572-4e71-4307-b7d8-4a0d2b97bea0" xlink:to="loc_ifrs-full_CostOfSales_217be760-6b5b-4fad-9007-ceebd93b5f0d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MiscellaneousOtherOperatingIncome_5fb721c8-d6c3-4780-bdc9-784f5b10d695" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_MiscellaneousOtherOperatingIncome"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_fd626572-4e71-4307-b7d8-4a0d2b97bea0" xlink:to="loc_ifrs-full_MiscellaneousOtherOperatingIncome_5fb721c8-d6c3-4780-bdc9-784f5b10d695" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/ConsolidatedStatementsofProfitorLoss_1" xlink:type="simple" xlink:href="bntx-20211231.xsd#ConsolidatedStatementsofProfitorLoss_1"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ConsolidatedStatementsofProfitorLoss_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_36fcee9a-3567-4e30-ab99-35b0023f94fe" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_ab25d7e5-d497-41f7-9f85-aca21e6e2f05" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_36fcee9a-3567-4e30-ab99-35b0023f94fe" xlink:to="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_ab25d7e5-d497-41f7-9f85-aca21e6e2f05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_85b4eced-b4ad-4a1f-ad04-9a132d9c4a32" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_36fcee9a-3567-4e30-ab99-35b0023f94fe" xlink:to="loc_ifrs-full_ProfitLossBeforeTax_85b4eced-b4ad-4a1f-ad04-9a132d9c4a32" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/ConsolidatedStatementsofComprehensiveIncomeLoss" xlink:type="simple" xlink:href="bntx-20211231.xsd#ConsolidatedStatementsofComprehensiveIncomeLoss"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ConsolidatedStatementsofComprehensiveIncomeLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_c1edee88-d5f7-4a42-a40a-b99519600c92" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_f7a0ea38-b261-45a5-9688-cead397cf498" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_c1edee88-d5f7-4a42-a40a-b99519600c92" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_f7a0ea38-b261-45a5-9688-cead397cf498" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_d60b8bb5-b2c3-4195-b21e-ebafc8d70fb0" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_c1773b09-f91f-491c-aafd-3d5ed7ed22df" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_d60b8bb5-b2c3-4195-b21e-ebafc8d70fb0" xlink:to="loc_ifrs-full_ProfitLoss_c1773b09-f91f-491c-aafd-3d5ed7ed22df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_53dcbef2-2508-46a9-a16d-76464c84fbf8" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_d60b8bb5-b2c3-4195-b21e-ebafc8d70fb0" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_53dcbef2-2508-46a9-a16d-76464c84fbf8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_d7b5bb4d-a0a8-4045-a6df-835e3290c4b8" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation_3794a65f-d368-4f96-bf4b-918d9a2f0bd2" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_d7b5bb4d-a0a8-4045-a6df-835e3290c4b8" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation_3794a65f-d368-4f96-bf4b-918d9a2f0bd2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/ConsolidatedStatementsofComprehensiveIncomeLoss_1" xlink:type="simple" xlink:href="bntx-20211231.xsd#ConsolidatedStatementsofComprehensiveIncomeLoss_1"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ConsolidatedStatementsofComprehensiveIncomeLoss_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_7519eba5-36a1-4356-a9c2-449451c19de5" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_8c0c6a02-ae1f-479b-9bab-96e5a35c8de2" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_7519eba5-36a1-4356-a9c2-449451c19de5" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_8c0c6a02-ae1f-479b-9bab-96e5a35c8de2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_fdf5aad0-c652-4380-b57f-bc7d5f3ff844" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_7519eba5-36a1-4356-a9c2-449451c19de5" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_fdf5aad0-c652-4380-b57f-bc7d5f3ff844" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/ConsolidatedStatementsofFinancialPosition" xlink:type="simple" xlink:href="bntx-20211231.xsd#ConsolidatedStatementsofFinancialPosition"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ConsolidatedStatementsofFinancialPosition" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_a915a665-f73d-4eb0-9d6e-474fe78fb9cb" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PropertyPlantAndEquipment_a7b5cde8-1ae4-491d-adac-8d50f2cd9824" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_a915a665-f73d-4eb0-9d6e-474fe78fb9cb" xlink:to="loc_ifrs-full_PropertyPlantAndEquipment_a7b5cde8-1ae4-491d-adac-8d50f2cd9824" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IntangibleAssetsAndGoodwill_80cfc55a-f6b2-4adb-baed-ae14c4306dd7" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IntangibleAssetsAndGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_a915a665-f73d-4eb0-9d6e-474fe78fb9cb" xlink:to="loc_ifrs-full_IntangibleAssetsAndGoodwill_80cfc55a-f6b2-4adb-baed-ae14c4306dd7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxAssets_7b0435c4-d721-4b8c-bab5-1b4e167888ee" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DeferredTaxAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_a915a665-f73d-4eb0-9d6e-474fe78fb9cb" xlink:to="loc_ifrs-full_DeferredTaxAssets_7b0435c4-d721-4b8c-bab5-1b4e167888ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RightofuseAssets_24f1579c-91dc-492b-b91f-7c6048fa4aca" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RightofuseAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_a915a665-f73d-4eb0-9d6e-474fe78fb9cb" xlink:to="loc_ifrs-full_RightofuseAssets_24f1579c-91dc-492b-b91f-7c6048fa4aca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentAssets_68cc1294-067e-4527-90f3-df3b323bf43a" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherNoncurrentAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_a915a665-f73d-4eb0-9d6e-474fe78fb9cb" xlink:to="loc_ifrs-full_OtherNoncurrentAssets_68cc1294-067e-4527-90f3-df3b323bf43a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentFinancialAssets_ee55c6b6-9c97-4fca-aec6-3ea00fb8079f" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherNoncurrentFinancialAssets"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_a915a665-f73d-4eb0-9d6e-474fe78fb9cb" xlink:to="loc_ifrs-full_OtherNoncurrentFinancialAssets_ee55c6b6-9c97-4fca-aec6-3ea00fb8079f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_DeferredExpenseNonCurrent_b5f9b647-c517-4558-a9fc-f69c92037d2a" xlink:href="bntx-20211231.xsd#bntx_DeferredExpenseNonCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_a915a665-f73d-4eb0-9d6e-474fe78fb9cb" xlink:to="loc_bntx_DeferredExpenseNonCurrent_b5f9b647-c517-4558-a9fc-f69c92037d2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_34127bb8-32cf-49dd-be71-0605ee93fcf2" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Equity"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherReserves_d02f8a61-ef5f-449c-b344-35bff9979ae6" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_34127bb8-32cf-49dd-be71-0605ee93fcf2" xlink:to="loc_ifrs-full_OtherReserves_d02f8a61-ef5f-449c-b344-35bff9979ae6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TreasuryShares_69bfbbe3-8001-49c2-92de-858eb1905043" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TreasuryShares"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_34127bb8-32cf-49dd-be71-0605ee93fcf2" xlink:to="loc_ifrs-full_TreasuryShares_69bfbbe3-8001-49c2-92de-858eb1905043" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapital_29f9f364-51c3-4efa-b7f6-c308d601e413" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IssuedCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_34127bb8-32cf-49dd-be71-0605ee93fcf2" xlink:to="loc_ifrs-full_IssuedCapital_29f9f364-51c3-4efa-b7f6-c308d601e413" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CapitalReserve_7592faac-7688-4339-a705-8a0777d3aa2e" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CapitalReserve"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_34127bb8-32cf-49dd-be71-0605ee93fcf2" xlink:to="loc_ifrs-full_CapitalReserve_7592faac-7688-4339-a705-8a0777d3aa2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RetainedEarnings_cf18af8d-9039-45e8-a6e5-36bd4ebb928e" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RetainedEarnings"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_34127bb8-32cf-49dd-be71-0605ee93fcf2" xlink:to="loc_ifrs-full_RetainedEarnings_cf18af8d-9039-45e8-a6e5-36bd4ebb928e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_1054bd42-b8b8-476f-a8db-5fb775f94d12" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentProvisions_5987f18e-7654-4215-9824-2eed6e016ef8" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentProvisions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_1054bd42-b8b8-476f-a8db-5fb775f94d12" xlink:to="loc_ifrs-full_CurrentProvisions_5987f18e-7654-4215-9824-2eed6e016ef8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentGovernmentGrants_5b43a928-9a9d-4bc5-b748-fc94688e4cb9" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentGovernmentGrants"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_1054bd42-b8b8-476f-a8db-5fb775f94d12" xlink:to="loc_ifrs-full_CurrentGovernmentGrants_5b43a928-9a9d-4bc5-b748-fc94688e4cb9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ShorttermBorrowings_a77d4e78-6522-4dee-a95b-5d399ca5ee26" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ShorttermBorrowings"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_1054bd42-b8b8-476f-a8db-5fb775f94d12" xlink:to="loc_ifrs-full_ShorttermBorrowings_a77d4e78-6522-4dee-a95b-5d399ca5ee26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentContractLiabilities_c9cf117f-fc20-4bff-a642-4edf913eb621" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentContractLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_1054bd42-b8b8-476f-a8db-5fb775f94d12" xlink:to="loc_ifrs-full_CurrentContractLiabilities_c9cf117f-fc20-4bff-a642-4edf913eb621" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentLiabilities_508c5e72-d9ca-42d6-9938-e9908175bcec" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherCurrentLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_1054bd42-b8b8-476f-a8db-5fb775f94d12" xlink:to="loc_ifrs-full_OtherCurrentLiabilities_508c5e72-d9ca-42d6-9938-e9908175bcec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentFinancialLiabilities_23abfe00-0b30-419c-bde2-dbd4ded2f041" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherCurrentFinancialLiabilities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_1054bd42-b8b8-476f-a8db-5fb775f94d12" xlink:to="loc_ifrs-full_OtherCurrentFinancialLiabilities_23abfe00-0b30-419c-bde2-dbd4ded2f041" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayables_9f8628df-bf92-4d53-9db3-84dc165ac19f" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TradeAndOtherCurrentPayables"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_1054bd42-b8b8-476f-a8db-5fb775f94d12" xlink:to="loc_ifrs-full_TradeAndOtherCurrentPayables_9f8628df-bf92-4d53-9db3-84dc165ac19f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxLiabilitiesCurrent_81ad8934-6665-4c74-b666-54fd01d191f6" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentTaxLiabilitiesCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_1054bd42-b8b8-476f-a8db-5fb775f94d12" xlink:to="loc_ifrs-full_CurrentTaxLiabilitiesCurrent_81ad8934-6665-4c74-b666-54fd01d191f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentRefundsProvision_675626d5-f089-4a92-8701-9897b2100422" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentRefundsProvision"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_1054bd42-b8b8-476f-a8db-5fb775f94d12" xlink:to="loc_ifrs-full_CurrentRefundsProvision_675626d5-f089-4a92-8701-9897b2100422" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_da5352a7-1295-4a64-8684-1a10f4debf6b" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LongtermBorrowings_9db98cda-bc23-409a-8c50-256e4e778fb9" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_LongtermBorrowings"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_da5352a7-1295-4a64-8684-1a10f4debf6b" xlink:to="loc_ifrs-full_LongtermBorrowings_9db98cda-bc23-409a-8c50-256e4e778fb9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentFinancialLiabilities_e5e56bca-6ddc-4702-a5c9-06a6800af13e" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherNoncurrentFinancialLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_da5352a7-1295-4a64-8684-1a10f4debf6b" xlink:to="loc_ifrs-full_OtherNoncurrentFinancialLiabilities_e5e56bca-6ddc-4702-a5c9-06a6800af13e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentContractLiabilities_22e912d2-2336-4423-9ed0-f57a3c80e0d1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentContractLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_da5352a7-1295-4a64-8684-1a10f4debf6b" xlink:to="loc_ifrs-full_NoncurrentContractLiabilities_22e912d2-2336-4423-9ed0-f57a3c80e0d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxLiabilitiesNoncurrent_d5693872-5812-47a9-a5a0-edd7abb852eb" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentTaxLiabilitiesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_da5352a7-1295-4a64-8684-1a10f4debf6b" xlink:to="loc_ifrs-full_CurrentTaxLiabilitiesNoncurrent_d5693872-5812-47a9-a5a0-edd7abb852eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentProvisions_48bd04a5-df5c-4fb0-8ff7-0a90cf2b5972" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentProvisions"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_da5352a7-1295-4a64-8684-1a10f4debf6b" xlink:to="loc_ifrs-full_NoncurrentProvisions_48bd04a5-df5c-4fb0-8ff7-0a90cf2b5972" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxLiabilities_f91f5d6c-f07a-42d7-9dad-7c33a414c45c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DeferredTaxLiabilities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_da5352a7-1295-4a64-8684-1a10f4debf6b" xlink:to="loc_ifrs-full_DeferredTaxLiabilities_f91f5d6c-f07a-42d7-9dad-7c33a414c45c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentLiabilities_0c8db873-5154-4c9d-8fa2-a93d750c4913" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherNoncurrentLiabilities"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_da5352a7-1295-4a64-8684-1a10f4debf6b" xlink:to="loc_ifrs-full_OtherNoncurrentLiabilities_0c8db873-5154-4c9d-8fa2-a93d750c4913" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Assets_ad4ee32a-e6c7-4270-afde-ba8e8259ad63" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_806e69ec-9cbc-415f-b546-ee2673b68a32" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_ad4ee32a-e6c7-4270-afde-ba8e8259ad63" xlink:to="loc_ifrs-full_NoncurrentAssets_806e69ec-9cbc-415f-b546-ee2673b68a32" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_912fa4a0-9480-485e-8ff8-51925cdfe740" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_ad4ee32a-e6c7-4270-afde-ba8e8259ad63" xlink:to="loc_ifrs-full_CurrentAssets_912fa4a0-9480-485e-8ff8-51925cdfe740" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_da47f211-b1dc-45d7-ac47-712d8feb23f6" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_6852e903-49fb-46bb-a6b7-6564b02476d6" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_da47f211-b1dc-45d7-ac47-712d8feb23f6" xlink:to="loc_ifrs-full_CashAndCashEquivalents_6852e903-49fb-46bb-a6b7-6564b02476d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentFinancialAssets_f65a5d4a-b7d5-45d3-8413-f078228b55fa" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherCurrentFinancialAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_da47f211-b1dc-45d7-ac47-712d8feb23f6" xlink:to="loc_ifrs-full_OtherCurrentFinancialAssets_f65a5d4a-b7d5-45d3-8413-f078228b55fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_DeferredExpenseCurrent_7cd86e5b-5084-4c8b-8f23-64cf9188f006" xlink:href="bntx-20211231.xsd#bntx_DeferredExpenseCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_da47f211-b1dc-45d7-ac47-712d8feb23f6" xlink:to="loc_bntx_DeferredExpenseCurrent_7cd86e5b-5084-4c8b-8f23-64cf9188f006" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentAssets_f13c8481-8305-4fd4-8de5-54f5d7e04dee" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherCurrentAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_da47f211-b1dc-45d7-ac47-712d8feb23f6" xlink:to="loc_ifrs-full_OtherCurrentAssets_f13c8481-8305-4fd4-8de5-54f5d7e04dee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Inventories_da4cd626-4f21-4a8d-b24e-0d7edb84269d" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Inventories"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_da47f211-b1dc-45d7-ac47-712d8feb23f6" xlink:to="loc_ifrs-full_Inventories_da4cd626-4f21-4a8d-b24e-0d7edb84269d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxAssetsCurrent_1a2f1d65-87b5-4dfc-a4ee-3b00cfa4fbcc" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentTaxAssetsCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_da47f211-b1dc-45d7-ac47-712d8feb23f6" xlink:to="loc_ifrs-full_CurrentTaxAssetsCurrent_1a2f1d65-87b5-4dfc-a4ee-3b00cfa4fbcc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentReceivables_b54c4ff3-bc7e-408e-8175-bf4830901154" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TradeAndOtherCurrentReceivables"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_da47f211-b1dc-45d7-ac47-712d8feb23f6" xlink:to="loc_ifrs-full_TradeAndOtherCurrentReceivables_b54c4ff3-bc7e-408e-8175-bf4830901154" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAndLiabilities_e2c294c3-9b0e-4559-b20f-b0b671a4e406" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EquityAndLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_4e807574-752a-42e1-aef3-d146996297b6" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_e2c294c3-9b0e-4559-b20f-b0b671a4e406" xlink:to="loc_ifrs-full_Liabilities_4e807574-752a-42e1-aef3-d146996297b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_e370cc99-78be-4f68-b824-fb4de24cecc7" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Equity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_e2c294c3-9b0e-4559-b20f-b0b671a4e406" xlink:to="loc_ifrs-full_Equity_e370cc99-78be-4f68-b824-fb4de24cecc7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_ed19edcb-36ff-4c1c-81a3-5e6e41222d40" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_e9832d86-18ad-43c6-92d3-2cdd208c3429" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_ed19edcb-36ff-4c1c-81a3-5e6e41222d40" xlink:to="loc_ifrs-full_CurrentLiabilities_e9832d86-18ad-43c6-92d3-2cdd208c3429" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_446edc7a-13db-4449-98ab-b23d39251cca" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_ed19edcb-36ff-4c1c-81a3-5e6e41222d40" xlink:to="loc_ifrs-full_NoncurrentLiabilities_446edc7a-13db-4449-98ab-b23d39251cca" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="bntx-20211231.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_5b1ec63e-3fff-4a5a-83b2-a94c1fea2ad8" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherAdjustmentsForNoncashItems_a9a485b8-b243-4e0d-bdf9-2f1551a6a2e8" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherAdjustmentsForNoncashItems"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_5b1ec63e-3fff-4a5a-83b2-a94c1fea2ad8" xlink:to="loc_ifrs-full_OtherAdjustmentsForNoncashItems_a9a485b8-b243-4e0d-bdf9-2f1551a6a2e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForFinanceCosts_1a1827b5-9981-468c-89e4-b8eb4f477d3c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForFinanceCosts"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_5b1ec63e-3fff-4a5a-83b2-a94c1fea2ad8" xlink:to="loc_ifrs-full_AdjustmentsForFinanceCosts_1a1827b5-9981-468c-89e4-b8eb4f477d3c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_061d933d-b196-47b7-923a-05e1cb5774a4" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_5b1ec63e-3fff-4a5a-83b2-a94c1fea2ad8" xlink:to="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_061d933d-b196-47b7-923a-05e1cb5774a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_AdjustmentsForIncreaseDecreaseInTradePayablesOtherLiabilitiesContractLiabilitiesAndProvisions_89056985-3347-4458-a442-55ec3263d12c" xlink:href="bntx-20211231.xsd#bntx_AdjustmentsForIncreaseDecreaseInTradePayablesOtherLiabilitiesContractLiabilitiesAndProvisions"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_5b1ec63e-3fff-4a5a-83b2-a94c1fea2ad8" xlink:to="loc_bntx_AdjustmentsForIncreaseDecreaseInTradePayablesOtherLiabilitiesContractLiabilitiesAndProvisions_89056985-3347-4458-a442-55ec3263d12c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForFinanceIncome_2cdf9bfd-92af-4af5-b75f-15a7b4a1ce35" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForFinanceIncome"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_5b1ec63e-3fff-4a5a-83b2-a94c1fea2ad8" xlink:to="loc_ifrs-full_AdjustmentsForFinanceIncome_2cdf9bfd-92af-4af5-b75f-15a7b4a1ce35" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment_86a1548c-c8f7-4ccd-87f8-233e840c4be9" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_5b1ec63e-3fff-4a5a-83b2-a94c1fea2ad8" xlink:to="loc_ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment_86a1548c-c8f7-4ccd-87f8-233e840c4be9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_f9199699-02a7-4a4a-a4b8-2145fbbf82a5" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_5b1ec63e-3fff-4a5a-83b2-a94c1fea2ad8" xlink:to="loc_ifrs-full_ProfitLossBeforeTax_f9199699-02a7-4a4a-a4b8-2145fbbf82a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_AdjustmentsForMovementsInGovernmentGrants_13efcd27-0c89-4d49-b3a3-bb135767a836" xlink:href="bntx-20211231.xsd#bntx_AdjustmentsForMovementsInGovernmentGrants"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_5b1ec63e-3fff-4a5a-83b2-a94c1fea2ad8" xlink:to="loc_bntx_AdjustmentsForMovementsInGovernmentGrants_13efcd27-0c89-4d49-b3a3-bb135767a836" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains_d021bf89-22a3-45a4-8466-16d3f2bbfa64" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_5b1ec63e-3fff-4a5a-83b2-a94c1fea2ad8" xlink:to="loc_ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains_d021bf89-22a3-45a4-8466-16d3f2bbfa64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_9e01a9b6-ff9e-453d-834a-5cc63d2be48e" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_5b1ec63e-3fff-4a5a-83b2-a94c1fea2ad8" xlink:to="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_9e01a9b6-ff9e-453d-834a-5cc63d2be48e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestReceivedClassifiedAsOperatingActivities_a0df001a-7001-44c2-a18c-0a58c54dac01" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_InterestReceivedClassifiedAsOperatingActivities"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_5b1ec63e-3fff-4a5a-83b2-a94c1fea2ad8" xlink:to="loc_ifrs-full_InterestReceivedClassifiedAsOperatingActivities_a0df001a-7001-44c2-a18c-0a58c54dac01" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_AdjustmentsForDecreaseIncreaseInTradeAccountsReceivableContractAssetsAndOtherAssets_a70ea5bd-7947-463c-bee3-649c356d7c60" xlink:href="bntx-20211231.xsd#bntx_AdjustmentsForDecreaseIncreaseInTradeAccountsReceivableContractAssetsAndOtherAssets"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_5b1ec63e-3fff-4a5a-83b2-a94c1fea2ad8" xlink:to="loc_bntx_AdjustmentsForDecreaseIncreaseInTradeAccountsReceivableContractAssetsAndOtherAssets_a70ea5bd-7947-463c-bee3-649c356d7c60" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForSharebasedPayments_53b4339b-defe-4926-983f-13820b5830d2" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForSharebasedPayments"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_5b1ec63e-3fff-4a5a-83b2-a94c1fea2ad8" xlink:to="loc_ifrs-full_AdjustmentsForSharebasedPayments_53b4339b-defe-4926-983f-13820b5830d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestPaidClassifiedAsOperatingActivities_e00b8d11-b2d1-4a4a-acef-822acb9ee329" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_InterestPaidClassifiedAsOperatingActivities"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_5b1ec63e-3fff-4a5a-83b2-a94c1fea2ad8" xlink:to="loc_ifrs-full_InterestPaidClassifiedAsOperatingActivities_e00b8d11-b2d1-4a4a-acef-822acb9ee329" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInInventories_8e808905-9cb7-4aa1-bcd4-c2a1a06fb2c9" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInInventories"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_5b1ec63e-3fff-4a5a-83b2-a94c1fea2ad8" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInInventories_8e808905-9cb7-4aa1-bcd4-c2a1a06fb2c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnFinancialLiabilitiesAtFairValueThroughProfitOrLoss_b5afdec1-74cd-478d-9fa4-e4e327a7713f" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_GainsLossesOnFinancialLiabilitiesAtFairValueThroughProfitOrLoss"/>
    <link:calculationArc order="16" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_5b1ec63e-3fff-4a5a-83b2-a94c1fea2ad8" xlink:to="loc_ifrs-full_GainsLossesOnFinancialLiabilitiesAtFairValueThroughProfitOrLoss_b5afdec1-74cd-478d-9fa4-e4e327a7713f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_dc4c4e92-2754-4908-b1fc-48a0be7fb0e0" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities_577dfb35-a862-41c9-ba5e-ac54c647fbe1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_dc4c4e92-2754-4908-b1fc-48a0be7fb0e0" xlink:to="loc_ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities_577dfb35-a862-41c9-ba5e-ac54c647fbe1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities_e0a0d4d4-8954-4bc0-a97c-c8cc5a517498" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_dc4c4e92-2754-4908-b1fc-48a0be7fb0e0" xlink:to="loc_ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities_e0a0d4d4-8954-4bc0-a97c-c8cc5a517498" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_000253d0-402c-494e-bbbf-7c75eea3c3ac" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_dc4c4e92-2754-4908-b1fc-48a0be7fb0e0" xlink:to="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_000253d0-402c-494e-bbbf-7c75eea3c3ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromIssuingShares_bb8872b3-3e9a-402a-9328-3b71655702b0" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProceedsFromIssuingShares"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_dc4c4e92-2754-4908-b1fc-48a0be7fb0e0" xlink:to="loc_ifrs-full_ProceedsFromIssuingShares_bb8872b3-3e9a-402a-9328-3b71655702b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_a17aaec9-4be2-44af-8d19-4170010bc26b" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_8bf4a378-bb8f-45bd-901b-7109da161ce0" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_a17aaec9-4be2-44af-8d19-4170010bc26b" xlink:to="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_8bf4a378-bb8f-45bd-901b-7109da161ce0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_c133a65d-e405-4d6e-9605-b878f19f64a2" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_a17aaec9-4be2-44af-8d19-4170010bc26b" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_c133a65d-e405-4d6e-9605-b878f19f64a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_bc878cc3-7128-44ab-9121-56f9b100cac7" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_a17aaec9-4be2-44af-8d19-4170010bc26b" xlink:to="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_bc878cc3-7128-44ab-9121-56f9b100cac7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_5b431235-c1b1-4be7-b323-97787b561fcd" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_5863331f-9662-49af-9b89-fc21f16cb230" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_5b431235-c1b1-4be7-b323-97787b561fcd" xlink:to="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_5863331f-9662-49af-9b89-fc21f16cb230" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_PurchaseOfIntangibleAssetsAndRightOfUseAssetsClassifiedAsInvestingActivities_869e26ef-b1f5-4b05-8d50-4ff016e4f0f1" xlink:href="bntx-20211231.xsd#bntx_PurchaseOfIntangibleAssetsAndRightOfUseAssetsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_5b431235-c1b1-4be7-b323-97787b561fcd" xlink:to="loc_bntx_PurchaseOfIntangibleAssetsAndRightOfUseAssetsClassifiedAsInvestingActivities_869e26ef-b1f5-4b05-8d50-4ff016e4f0f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities_e6f96918-4a13-43c4-853d-a4e490f09d1f" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_5b431235-c1b1-4be7-b323-97787b561fcd" xlink:to="loc_ifrs-full_CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities_e6f96918-4a13-43c4-853d-a4e490f09d1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_43f8a95b-79d0-49cd-a1ab-81e364b38814" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_5b431235-c1b1-4be7-b323-97787b561fcd" xlink:to="loc_ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_43f8a95b-79d0-49cd-a1ab-81e364b38814" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_PurchaseOfEquityInvestmentsDesignateAtFairValueThroughOtherComprehensiveIncome_28ed1d67-0c5e-4e3c-815e-9c27be6049d4" xlink:href="bntx-20211231.xsd#bntx_PurchaseOfEquityInvestmentsDesignateAtFairValueThroughOtherComprehensiveIncome"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_5b431235-c1b1-4be7-b323-97787b561fcd" xlink:to="loc_bntx_PurchaseOfEquityInvestmentsDesignateAtFairValueThroughOtherComprehensiveIncome_28ed1d67-0c5e-4e3c-815e-9c27be6049d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_PurchaseOfCashDepositWithATermOfMoreThanThreeMonths_5a6c0844-f3bb-4488-ac9c-8c0f750c96b2" xlink:href="bntx-20211231.xsd#bntx_PurchaseOfCashDepositWithATermOfMoreThanThreeMonths"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_5b431235-c1b1-4be7-b323-97787b561fcd" xlink:to="loc_bntx_PurchaseOfCashDepositWithATermOfMoreThanThreeMonths_5a6c0844-f3bb-4488-ac9c-8c0f750c96b2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/BusinessCombinationsSummaryofFairValuesofIdentifiableNetAssetsDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#BusinessCombinationsSummaryofFairValuesofIdentifiableNetAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/BusinessCombinationsSummaryofFairValuesofIdentifiableNetAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_bntx_IdentifiableAssetsAcquiredLiabilitiesAssumedAndGoodwillNetOfBargainPurchase_d98e8255-781f-48f8-bbfa-81d936ee90d3" xlink:href="bntx-20211231.xsd#bntx_IdentifiableAssetsAcquiredLiabilitiesAssumedAndGoodwillNetOfBargainPurchase"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GoodwillRecognisedAsOfAcquisitionDate_df846a4b-0b4a-4a92-bd95-61e1019106a1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_GoodwillRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_IdentifiableAssetsAcquiredLiabilitiesAssumedAndGoodwillNetOfBargainPurchase_d98e8255-781f-48f8-bbfa-81d936ee90d3" xlink:to="loc_ifrs-full_GoodwillRecognisedAsOfAcquisitionDate_df846a4b-0b4a-4a92-bd95-61e1019106a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IdentifiableAssetsAcquiredLiabilitiesAssumed_f1974053-8394-4eec-9e1e-e1f8eabc7350" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IdentifiableAssetsAcquiredLiabilitiesAssumed"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_IdentifiableAssetsAcquiredLiabilitiesAssumedAndGoodwillNetOfBargainPurchase_d98e8255-781f-48f8-bbfa-81d936ee90d3" xlink:to="loc_ifrs-full_IdentifiableAssetsAcquiredLiabilitiesAssumed_f1974053-8394-4eec-9e1e-e1f8eabc7350" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_AssetsRecognisedAsOfAcquisitionDate_a7e9d0d9-d221-47c9-bb8b-99d8d4c0777a" xlink:href="bntx-20211231.xsd#bntx_AssetsRecognisedAsOfAcquisitionDate"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_OtherNoncurrentAndCurrentAssetsRecognisedAsOfAcquisitionDate_a9bdf901-139b-4eb4-a0fa-4950a5f89fb7" xlink:href="bntx-20211231.xsd#bntx_OtherNoncurrentAndCurrentAssetsRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_AssetsRecognisedAsOfAcquisitionDate_a7e9d0d9-d221-47c9-bb8b-99d8d4c0777a" xlink:to="loc_bntx_OtherNoncurrentAndCurrentAssetsRecognisedAsOfAcquisitionDate_a9bdf901-139b-4eb4-a0fa-4950a5f89fb7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IdentifiableIntangibleAssetsRecognisedAsOfAcquisitionDate_454c4e0e-e2a0-4753-9ef7-73126863e30f" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IdentifiableIntangibleAssetsRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_AssetsRecognisedAsOfAcquisitionDate_a7e9d0d9-d221-47c9-bb8b-99d8d4c0777a" xlink:to="loc_ifrs-full_IdentifiableIntangibleAssetsRecognisedAsOfAcquisitionDate_454c4e0e-e2a0-4753-9ef7-73126863e30f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PropertyPlantAndEquipmentRecognisedAsOfAcquisitionDate_c6b02deb-3ff6-46a1-bf4e-3d8548dd419c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PropertyPlantAndEquipmentRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_AssetsRecognisedAsOfAcquisitionDate_a7e9d0d9-d221-47c9-bb8b-99d8d4c0777a" xlink:to="loc_ifrs-full_PropertyPlantAndEquipmentRecognisedAsOfAcquisitionDate_c6b02deb-3ff6-46a1-bf4e-3d8548dd419c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InventoryRecognisedAsOfAcquisitionDate_3a984a4b-c02b-4e9c-ac8e-3fe80771e75b" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_InventoryRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_AssetsRecognisedAsOfAcquisitionDate_a7e9d0d9-d221-47c9-bb8b-99d8d4c0777a" xlink:to="loc_ifrs-full_InventoryRecognisedAsOfAcquisitionDate_3a984a4b-c02b-4e9c-ac8e-3fe80771e75b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalentsRecognisedAsOfAcquisitionDate_6c48c5d8-c223-44ee-b6ff-58513a28de77" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashAndCashEquivalentsRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_AssetsRecognisedAsOfAcquisitionDate_a7e9d0d9-d221-47c9-bb8b-99d8d4c0777a" xlink:to="loc_ifrs-full_CashAndCashEquivalentsRecognisedAsOfAcquisitionDate_6c48c5d8-c223-44ee-b6ff-58513a28de77" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_RightOfUseAssetsRecognisedAsOfAcquisitionDate_b8fd4831-5a1b-4cd9-bb9e-764773042f33" xlink:href="bntx-20211231.xsd#bntx_RightOfUseAssetsRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_AssetsRecognisedAsOfAcquisitionDate_a7e9d0d9-d221-47c9-bb8b-99d8d4c0777a" xlink:to="loc_bntx_RightOfUseAssetsRecognisedAsOfAcquisitionDate_b8fd4831-5a1b-4cd9-bb9e-764773042f33" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AcquisitiondateFairValueOfTotalConsiderationTransferred_334f6c48-d66c-4cbd-b014-72cffbdcd413" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AcquisitiondateFairValueOfTotalConsiderationTransferred"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ContingentConsiderationRecognisedAsOfAcquisitionDate_71390520-e98f-48d3-a9d7-9c4c54125e5c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ContingentConsiderationRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_AcquisitiondateFairValueOfTotalConsiderationTransferred_334f6c48-d66c-4cbd-b014-72cffbdcd413" xlink:to="loc_ifrs-full_ContingentConsiderationRecognisedAsOfAcquisitionDate_71390520-e98f-48d3-a9d7-9c4c54125e5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashTransferred_c6f85dbc-766d-4bb5-8704-2e018d71aaae" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashTransferred"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_AcquisitiondateFairValueOfTotalConsiderationTransferred_334f6c48-d66c-4cbd-b014-72cffbdcd413" xlink:to="loc_ifrs-full_CashTransferred_c6f85dbc-766d-4bb5-8704-2e018d71aaae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_SharesIssuedAtFairValue_d75d0933-374b-43b3-95f3-d20b72f358a6" xlink:href="bntx-20211231.xsd#bntx_SharesIssuedAtFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_AcquisitiondateFairValueOfTotalConsiderationTransferred_334f6c48-d66c-4cbd-b014-72cffbdcd413" xlink:to="loc_bntx_SharesIssuedAtFairValue_d75d0933-374b-43b3-95f3-d20b72f358a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IdentifiableAssetsAcquiredLiabilitiesAssumed_4f3be40d-e673-4296-ba46-0fb35b939101" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IdentifiableAssetsAcquiredLiabilitiesAssumed"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_LiabilitiesRecognisedAsOfAcquisitionDate_7604e6f6-7f74-46c0-bcde-0db6d139b452" xlink:href="bntx-20211231.xsd#bntx_LiabilitiesRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IdentifiableAssetsAcquiredLiabilitiesAssumed_4f3be40d-e673-4296-ba46-0fb35b939101" xlink:to="loc_bntx_LiabilitiesRecognisedAsOfAcquisitionDate_7604e6f6-7f74-46c0-bcde-0db6d139b452" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_AssetsRecognisedAsOfAcquisitionDate_6165e200-c975-42a0-94f0-33f667961e53" xlink:href="bntx-20211231.xsd#bntx_AssetsRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IdentifiableAssetsAcquiredLiabilitiesAssumed_4f3be40d-e673-4296-ba46-0fb35b939101" xlink:to="loc_bntx_AssetsRecognisedAsOfAcquisitionDate_6165e200-c975-42a0-94f0-33f667961e53" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_LiabilitiesRecognisedAsOfAcquisitionDate_48222dbf-b2fa-4577-b495-7f2b697014e8" xlink:href="bntx-20211231.xsd#bntx_LiabilitiesRecognisedAsOfAcquisitionDate"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_TradePayablesRecognisedAsOfAcquisitionDate_26a0b3a0-b4fb-4a7d-a912-77e1e3a1e433" xlink:href="bntx-20211231.xsd#bntx_TradePayablesRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_LiabilitiesRecognisedAsOfAcquisitionDate_48222dbf-b2fa-4577-b495-7f2b697014e8" xlink:to="loc_bntx_TradePayablesRecognisedAsOfAcquisitionDate_26a0b3a0-b4fb-4a7d-a912-77e1e3a1e433" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_OtherCurrentAndNonCurrentLiabilitiesRecognisedAsOfAcquisitionDate_24a7e4c2-aad2-40a1-95bb-54a5c259272c" xlink:href="bntx-20211231.xsd#bntx_OtherCurrentAndNonCurrentLiabilitiesRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_LiabilitiesRecognisedAsOfAcquisitionDate_48222dbf-b2fa-4577-b495-7f2b697014e8" xlink:to="loc_bntx_OtherCurrentAndNonCurrentLiabilitiesRecognisedAsOfAcquisitionDate_24a7e4c2-aad2-40a1-95bb-54a5c259272c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ProvisionsNonCurrentAndCurrentRecognisedAsOfAcquisitionDate_aa21f16b-fe97-447a-bbb9-78fe738e001c" xlink:href="bntx-20211231.xsd#bntx_ProvisionsNonCurrentAndCurrentRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_LiabilitiesRecognisedAsOfAcquisitionDate_48222dbf-b2fa-4577-b495-7f2b697014e8" xlink:to="loc_bntx_ProvisionsNonCurrentAndCurrentRecognisedAsOfAcquisitionDate_aa21f16b-fe97-447a-bbb9-78fe738e001c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/IncomeandExpensesFinanceIncomeDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#IncomeandExpensesFinanceIncomeDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/IncomeandExpensesFinanceIncomeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_7f054b25-a8be-412e-afa8-e611fea7362f" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinanceIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromInterest_437ecdc7-b317-45f9-803c-b70b252a3875" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RevenueFromInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncome_7f054b25-a8be-412e-afa8-e611fea7362f" xlink:to="loc_ifrs-full_RevenueFromInterest_437ecdc7-b317-45f9-803c-b70b252a3875" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NetForeignExchangeGain_e674f244-4378-4a43-8665-aed32dce02c0" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NetForeignExchangeGain"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncome_7f054b25-a8be-412e-afa8-e611fea7362f" xlink:to="loc_ifrs-full_NetForeignExchangeGain_e674f244-4378-4a43-8665-aed32dce02c0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/IncomeandExpensesFinanceExpenseDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#IncomeandExpensesFinanceExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/IncomeandExpensesFinanceExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_abcbaba1-cfdf-487f-903c-0744a7d8defa" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinanceCosts"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestExpenseOnLeaseLiabilities_4d865cb4-c59a-4c64-bce5-bae0213f4f54" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_InterestExpenseOnLeaseLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_abcbaba1-cfdf-487f-903c-0744a7d8defa" xlink:to="loc_ifrs-full_InterestExpenseOnLeaseLiabilities_4d865cb4-c59a-4c64-bce5-bae0213f4f54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_InterestExpenseOnFinancialAssets_cdc0aebb-c001-48e4-9e4c-c8832a8b60d5" xlink:href="bntx-20211231.xsd#bntx_InterestExpenseOnFinancialAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_abcbaba1-cfdf-487f-903c-0744a7d8defa" xlink:to="loc_bntx_InterestExpenseOnFinancialAssets_cdc0aebb-c001-48e4-9e4c-c8832a8b60d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NetForeignExchangeLoss_ec3462e2-72c3-4b11-9116-43df805d14a1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NetForeignExchangeLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_abcbaba1-cfdf-487f-903c-0744a7d8defa" xlink:to="loc_ifrs-full_NetForeignExchangeLoss_ec3462e2-72c3-4b11-9116-43df805d14a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_FairValueAdjustmentsOfFinancialInstrumentsMeasuredAtFairValue_eada326a-ac9b-4f5a-ac92-ddc4c88aa3db" xlink:href="bntx-20211231.xsd#bntx_FairValueAdjustmentsOfFinancialInstrumentsMeasuredAtFairValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_abcbaba1-cfdf-487f-903c-0744a7d8defa" xlink:to="loc_bntx_FairValueAdjustmentsOfFinancialInstrumentsMeasuredAtFairValue_eada326a-ac9b-4f5a-ac92-ddc4c88aa3db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_AmortizationOfFinancialInstruments_82b923b5-1156-46b8-8a80-863997a54777" xlink:href="bntx-20211231.xsd#bntx_AmortizationOfFinancialInstruments"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_abcbaba1-cfdf-487f-903c-0744a7d8defa" xlink:to="loc_bntx_AmortizationOfFinancialInstruments_82b923b5-1156-46b8-8a80-863997a54777" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/IncomeandExpensesEmployeeBenefitsExpenseDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#IncomeandExpensesEmployeeBenefitsExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/IncomeandExpensesEmployeeBenefitsExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EmployeeBenefitsExpense_b5c5e462-faeb-420c-9b90-faf65001c32f" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EmployeeBenefitsExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SocialSecurityContributions_224a564c-5bc3-4086-9210-0396d564be2a" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SocialSecurityContributions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EmployeeBenefitsExpense_b5c5e462-faeb-420c-9b90-faf65001c32f" xlink:to="loc_ifrs-full_SocialSecurityContributions_224a564c-5bc3-4086-9210-0396d564be2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PostemploymentBenefitExpenseDefinedBenefitPlans_cdb2bacb-b976-48a3-af82-905ac9d35070" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PostemploymentBenefitExpenseDefinedBenefitPlans"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EmployeeBenefitsExpense_b5c5e462-faeb-420c-9b90-faf65001c32f" xlink:to="loc_ifrs-full_PostemploymentBenefitExpenseDefinedBenefitPlans_cdb2bacb-b976-48a3-af82-905ac9d35070" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_WagesAndSalaries_d479008c-2bf9-41c7-8a7c-678adffb95ec" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_WagesAndSalaries"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EmployeeBenefitsExpense_b5c5e462-faeb-420c-9b90-faf65001c32f" xlink:to="loc_ifrs-full_WagesAndSalaries_d479008c-2bf9-41c7-8a7c-678adffb95ec" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/IncomeTaxSummaryofCurrentandDeferredTaxExpenseDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#IncomeTaxSummaryofCurrentandDeferredTaxExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/IncomeTaxSummaryofCurrentandDeferredTaxExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_e0236fb1-f0c4-4b78-89cc-0efa60bd5f42" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxExpenseIncome_fad69d7c-07a3-4994-9ce9-1bc1235b8336" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DeferredTaxExpenseIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_e0236fb1-f0c4-4b78-89cc-0efa60bd5f42" xlink:to="loc_ifrs-full_DeferredTaxExpenseIncome_fad69d7c-07a3-4994-9ce9-1bc1235b8336" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxExpenseIncome_2b1207c4-8def-4e00-9cf9-2cb687c92ced" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentTaxExpenseIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_e0236fb1-f0c4-4b78-89cc-0efa60bd5f42" xlink:to="loc_ifrs-full_CurrentTaxExpenseIncome_2b1207c4-8def-4e00-9cf9-2cb687c92ced" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/IncomeTaxSummaryofReconciliationofExpectedIncomeTaxBenefittoActualIncomeDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#IncomeTaxSummaryofReconciliationofExpectedIncomeTaxBenefittoActualIncomeDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/IncomeTaxSummaryofReconciliationofExpectedIncomeTaxBenefittoActualIncomeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_cc4c172a-c75f-48f3-8214-cc039eb43724" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TaxEffectFromChangeInTaxRate_e6bee609-d495-4bfa-a0d5-f322be685ee1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TaxEffectFromChangeInTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_cc4c172a-c75f-48f3-8214-cc039eb43724" xlink:to="loc_ifrs-full_TaxEffectFromChangeInTaxRate_e6bee609-d495-4bfa-a0d5-f322be685ee1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_NonRecognitionOfTaxEffectOnShareBasedPaymentExpenses_952914a4-7163-40f2-89ae-ffd3468db1ee" xlink:href="bntx-20211231.xsd#bntx_NonRecognitionOfTaxEffectOnShareBasedPaymentExpenses"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_cc4c172a-c75f-48f3-8214-cc039eb43724" xlink:to="loc_bntx_NonRecognitionOfTaxEffectOnShareBasedPaymentExpenses_952914a4-7163-40f2-89ae-ffd3468db1ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TaxExpenseIncomeAtApplicableTaxRate_72eb01ad-4a07-49dd-a2f9-946c443ed59a" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TaxExpenseIncomeAtApplicableTaxRate"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_cc4c172a-c75f-48f3-8214-cc039eb43724" xlink:to="loc_ifrs-full_TaxExpenseIncomeAtApplicableTaxRate_72eb01ad-4a07-49dd-a2f9-946c443ed59a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_TaxEffectiveEquityTransactionCosts_fc71becf-ec32-486c-b2cc-915757c64dde" xlink:href="bntx-20211231.xsd#bntx_TaxEffectiveEquityTransactionCosts"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_cc4c172a-c75f-48f3-8214-cc039eb43724" xlink:to="loc_bntx_TaxEffectiveEquityTransactionCosts_fc71becf-ec32-486c-b2cc-915757c64dde" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherTaxEffectsForReconciliationBetweenAccountingProfitAndTaxExpenseIncome_131a283c-25fb-42a1-ad5c-97cd259bdfc8" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherTaxEffectsForReconciliationBetweenAccountingProfitAndTaxExpenseIncome"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_cc4c172a-c75f-48f3-8214-cc039eb43724" xlink:to="loc_ifrs-full_OtherTaxEffectsForReconciliationBetweenAccountingProfitAndTaxExpenseIncome_131a283c-25fb-42a1-ad5c-97cd259bdfc8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForCurrentTaxOfPriorPeriod_9979867a-45c8-41a1-a87f-f72e4fb673de" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForCurrentTaxOfPriorPeriod"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_cc4c172a-c75f-48f3-8214-cc039eb43724" xlink:to="loc_ifrs-full_AdjustmentsForCurrentTaxOfPriorPeriod_9979867a-45c8-41a1-a87f-f72e4fb673de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_NonTaxEffectiveBargainPurchase_93f73746-833e-435f-9af2-851247f16909" xlink:href="bntx-20211231.xsd#bntx_NonTaxEffectiveBargainPurchase"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_cc4c172a-c75f-48f3-8214-cc039eb43724" xlink:to="loc_bntx_NonTaxEffectiveBargainPurchase_93f73746-833e-435f-9af2-851247f16909" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TaxEffectOfRevenuesExemptFromTaxation2011_12991b7a-ef28-4fcf-9919-649c5df2764c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TaxEffectOfRevenuesExemptFromTaxation2011"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_cc4c172a-c75f-48f3-8214-cc039eb43724" xlink:to="loc_ifrs-full_TaxEffectOfRevenuesExemptFromTaxation2011_12991b7a-ef28-4fcf-9919-649c5df2764c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_TaxEffectOfChangeInValuationAllowance_f9318b26-20a3-4529-bf5b-23b6faf4a5c8" xlink:href="bntx-20211231.xsd#bntx_TaxEffectOfChangeInValuationAllowance"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_cc4c172a-c75f-48f3-8214-cc039eb43724" xlink:to="loc_bntx_TaxEffectOfChangeInValuationAllowance_f9318b26-20a3-4529-bf5b-23b6faf4a5c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TaxEffectOfForeignTaxRates_f215a0ef-e91b-45c0-8ecd-2978491332c2" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TaxEffectOfForeignTaxRates"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_cc4c172a-c75f-48f3-8214-cc039eb43724" xlink:to="loc_ifrs-full_TaxEffectOfForeignTaxRates_f215a0ef-e91b-45c0-8ecd-2978491332c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TaxEffectOfExpenseNotDeductibleInDeterminingTaxableProfitTaxLoss_e6b7d3e8-d55e-41f3-b8ff-e09413a0766c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TaxEffectOfExpenseNotDeductibleInDeterminingTaxableProfitTaxLoss"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_cc4c172a-c75f-48f3-8214-cc039eb43724" xlink:to="loc_ifrs-full_TaxEffectOfExpenseNotDeductibleInDeterminingTaxableProfitTaxLoss_e6b7d3e8-d55e-41f3-b8ff-e09413a0766c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_TaxEffectOfDeviationDueToLocalTaxBasis_e9d8446f-be8a-43f9-9ed8-7bf1b6f12cc1" xlink:href="bntx-20211231.xsd#bntx_TaxEffectOfDeviationDueToLocalTaxBasis"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_cc4c172a-c75f-48f3-8214-cc039eb43724" xlink:to="loc_bntx_TaxEffectOfDeviationDueToLocalTaxBasis_e9d8446f-be8a-43f9-9ed8-7bf1b6f12cc1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TaxEffectOfTaxLosses_e9190318-3d36-4568-8863-3f9eda82ee48" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TaxEffectOfTaxLosses"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_cc4c172a-c75f-48f3-8214-cc039eb43724" xlink:to="loc_ifrs-full_TaxEffectOfTaxLosses_e9190318-3d36-4568-8863-3f9eda82ee48" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/FinancialAssetsandFinancialLiabilitiesSummaryofFinancialAssetsatAmortizedCostDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#FinancialAssetsandFinancialLiabilitiesSummaryofFinancialAssetsatAmortizedCostDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/FinancialAssetsandFinancialLiabilitiesSummaryofFinancialAssetsatAmortizedCostDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialAssets_a2bdf74c-0093-4a1e-bcfb-d1c746f303fd" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinancialAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialAssets_f2509575-7bee-4b56-8c71-479de8e78f41" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentFinancialAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialAssets_a2bdf74c-0093-4a1e-bcfb-d1c746f303fd" xlink:to="loc_ifrs-full_NoncurrentFinancialAssets_f2509575-7bee-4b56-8c71-479de8e78f41" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentFinancialAssets_4725a06c-51b9-40c7-8bb5-839cfa048f99" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentFinancialAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialAssets_a2bdf74c-0093-4a1e-bcfb-d1c746f303fd" xlink:to="loc_ifrs-full_CurrentFinancialAssets_4725a06c-51b9-40c7-8bb5-839cfa048f99" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/FinancialAssetsandFinancialLiabilitiesSummaryofFinancialLiabilitiesDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#FinancialAssetsandFinancialLiabilitiesSummaryofFinancialLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/FinancialAssetsandFinancialLiabilitiesSummaryofFinancialLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialLiabilities_c3bdb951-4648-4b19-ad8c-8e411006a62e" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinancialLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialLiabilities_630cdae6-ec1f-4d1e-b846-e7aec9a81216" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentFinancialLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_c3bdb951-4648-4b19-ad8c-8e411006a62e" xlink:to="loc_ifrs-full_NoncurrentFinancialLiabilities_630cdae6-ec1f-4d1e-b846-e7aec9a81216" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentFinancialLiabilities_975c0ad6-efef-4182-be04-3c96d262b619" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentFinancialLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_c3bdb951-4648-4b19-ad8c-8e411006a62e" xlink:to="loc_ifrs-full_CurrentFinancialLiabilities_975c0ad6-efef-4182-be04-3c96d262b619" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialLiabilitiesAtFairValue_48540c0b-c98c-471e-a85d-ef272377db99" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinancialLiabilitiesAtFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_DerivativeFinancialLiabilitiesNotDesignatedAsHedgingInstrumentsAtFairValue_7b65234b-e872-4e5c-922c-da7d7282c6a1" xlink:href="bntx-20211231.xsd#bntx_DerivativeFinancialLiabilitiesNotDesignatedAsHedgingInstrumentsAtFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilitiesAtFairValue_48540c0b-c98c-471e-a85d-ef272377db99" xlink:to="loc_bntx_DerivativeFinancialLiabilitiesNotDesignatedAsHedgingInstrumentsAtFairValue_7b65234b-e872-4e5c-922c-da7d7282c6a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialLiabilitiesAtFairValueThroughProfitOrLoss_2f064dfd-45ab-4ea9-ba1d-e17963eaf9e3" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinancialLiabilitiesAtFairValueThroughProfitOrLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilitiesAtFairValue_48540c0b-c98c-471e-a85d-ef272377db99" xlink:to="loc_ifrs-full_FinancialLiabilitiesAtFairValueThroughProfitOrLoss_2f064dfd-45ab-4ea9-ba1d-e17963eaf9e3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialLiabilitiesAtAmortisedCost_17921b45-b37f-4ee0-ac7c-0dda8bddc92a" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinancialLiabilitiesAtAmortisedCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialLiabilitiesAtAmortisedCost_34bad4f4-fa69-4398-823e-17dc4db30d2b" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentFinancialLiabilitiesAtAmortisedCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilitiesAtAmortisedCost_17921b45-b37f-4ee0-ac7c-0dda8bddc92a" xlink:to="loc_ifrs-full_NoncurrentFinancialLiabilitiesAtAmortisedCost_34bad4f4-fa69-4398-823e-17dc4db30d2b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentFinancialLiabilitiesAtAmortisedCost_91fc6f81-5917-4697-b694-47eedd38bc3c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentFinancialLiabilitiesAtAmortisedCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilitiesAtAmortisedCost_17921b45-b37f-4ee0-ac7c-0dda8bddc92a" xlink:to="loc_ifrs-full_CurrentFinancialLiabilitiesAtAmortisedCost_91fc6f81-5917-4697-b694-47eedd38bc3c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/FinancialAssetsandFinancialLiabilitiesSummaryofFinancialLiabilitiesDetails_1" xlink:type="simple" xlink:href="bntx-20211231.xsd#FinancialAssetsandFinancialLiabilitiesSummaryofFinancialLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/FinancialAssetsandFinancialLiabilitiesSummaryofFinancialLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialLiabilities_63336a3c-c666-4407-a9c2-6fe00132dbe9" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinancialLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialLiabilitiesAtFairValue_69824c94-c73d-43a9-aba8-f725af4fb8f4" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinancialLiabilitiesAtFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_63336a3c-c666-4407-a9c2-6fe00132dbe9" xlink:to="loc_ifrs-full_FinancialLiabilitiesAtFairValue_69824c94-c73d-43a9-aba8-f725af4fb8f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialLiabilitiesAtAmortisedCost_4ceee893-5540-40ae-ab16-49fe6092556f" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinancialLiabilitiesAtAmortisedCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_63336a3c-c666-4407-a9c2-6fe00132dbe9" xlink:to="loc_ifrs-full_FinancialLiabilitiesAtAmortisedCost_4ceee893-5540-40ae-ab16-49fe6092556f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/FinancialAssetsandFinancialLiabilitiesSummaryofMaturityProfileofFinancialLiabilitiesBasedonContractualUndiscountedPaymentsDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#FinancialAssetsandFinancialLiabilitiesSummaryofMaturityProfileofFinancialLiabilitiesBasedonContractualUndiscountedPaymentsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/FinancialAssetsandFinancialLiabilitiesSummaryofMaturityProfileofFinancialLiabilitiesBasedonContractualUndiscountedPaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialLiabilities_2239fdea-6ae9-4aa3-ac27-9695ee345e7b" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinancialLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_InterestBearingLoansAndBorrowings_ae592a2d-e312-40f1-af01-4c9d7d238b8d" xlink:href="bntx-20211231.xsd#bntx_InterestBearingLoansAndBorrowings"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_2239fdea-6ae9-4aa3-ac27-9695ee345e7b" xlink:to="loc_bntx_InterestBearingLoansAndBorrowings_ae592a2d-e312-40f1-af01-4c9d7d238b8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherFinancialLiabilities_39ec79f0-4020-4813-bd6b-372f98d020d4" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherFinancialLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_2239fdea-6ae9-4aa3-ac27-9695ee345e7b" xlink:to="loc_ifrs-full_OtherFinancialLiabilities_39ec79f0-4020-4813-bd6b-372f98d020d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherPayables_b0d1fc54-27ce-453d-8728-32bd5aad9cc5" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TradeAndOtherPayables"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_2239fdea-6ae9-4aa3-ac27-9695ee345e7b" xlink:to="loc_ifrs-full_TradeAndOtherPayables_b0d1fc54-27ce-453d-8728-32bd5aad9cc5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ContingentLiabilitiesRecognisedInBusinessCombination_ae246898-fe63-4713-9996-640041e3beee" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ContingentLiabilitiesRecognisedInBusinessCombination"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_2239fdea-6ae9-4aa3-ac27-9695ee345e7b" xlink:to="loc_ifrs-full_ContingentLiabilitiesRecognisedInBusinessCombination_ae246898-fe63-4713-9996-640041e3beee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LeaseLiabilities_d1428cfe-ee91-4d57-b0fb-6e5f6a13a796" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_LeaseLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_2239fdea-6ae9-4aa3-ac27-9695ee345e7b" xlink:to="loc_ifrs-full_LeaseLiabilities_d1428cfe-ee91-4d57-b0fb-6e5f6a13a796" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DerivativeFinancialLiabilities_b7e0cd65-0a4b-4b19-bf56-e9fffffc6ac4" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DerivativeFinancialLiabilities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_2239fdea-6ae9-4aa3-ac27-9695ee345e7b" xlink:to="loc_ifrs-full_DerivativeFinancialLiabilities_b7e0cd65-0a4b-4b19-bf56-e9fffffc6ac4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/InventoriesSummaryofInventoriesDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#InventoriesSummaryofInventoriesDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/InventoriesSummaryofInventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Inventories_c6850fa0-f478-4234-9cec-132d97122485" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Inventories"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentRawMaterialsAndCurrentProductionSupplies_bed0f7b5-a75e-4d00-bf3c-416a37967028" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentRawMaterialsAndCurrentProductionSupplies"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Inventories_c6850fa0-f478-4234-9cec-132d97122485" xlink:to="loc_ifrs-full_CurrentRawMaterialsAndCurrentProductionSupplies_bed0f7b5-a75e-4d00-bf3c-416a37967028" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinishedGoods_7d9fdad5-cc88-4aa5-aece-82be865b0180" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinishedGoods"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Inventories_c6850fa0-f478-4234-9cec-132d97122485" xlink:to="loc_ifrs-full_FinishedGoods_7d9fdad5-cc88-4aa5-aece-82be865b0180" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_WorkInProgress_fe75aeb0-d14a-4198-bcdf-7c03eb8dcc62" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_WorkInProgress"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Inventories_c6850fa0-f478-4234-9cec-132d97122485" xlink:to="loc_ifrs-full_WorkInProgress_fe75aeb0-d14a-4198-bcdf-7c03eb8dcc62" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/OtherAssetsSummaryofOtherAssetsDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#OtherAssetsSummaryofOtherAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/OtherAssetsSummaryofOtherAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherAssets_4e3676e5-71e2-4f3c-bf9e-b5c14cdb2f43" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentAssets_6f1c5443-e47b-490c-abda-4d9afa3eacce" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherCurrentAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherAssets_4e3676e5-71e2-4f3c-bf9e-b5c14cdb2f43" xlink:to="loc_ifrs-full_OtherCurrentAssets_6f1c5443-e47b-490c-abda-4d9afa3eacce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentAssets_794fcf91-a6c2-42d3-b8a0-5278c0962be2" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherNoncurrentAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherAssets_4e3676e5-71e2-4f3c-bf9e-b5c14cdb2f43" xlink:to="loc_ifrs-full_OtherNoncurrentAssets_794fcf91-a6c2-42d3-b8a0-5278c0962be2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/OtherAssetsSummaryofOtherAssetsDetails_1" xlink:type="simple" xlink:href="bntx-20211231.xsd#OtherAssetsSummaryofOtherAssetsDetails_1"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/OtherAssetsSummaryofOtherAssetsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherAssets_714a5748-12b3-4c01-83dc-a855f9060a23" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentPrepaidExpenses_d4304754-13e8-45bf-9e94-fd1d337622ee" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentPrepaidExpenses"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherAssets_714a5748-12b3-4c01-83dc-a855f9060a23" xlink:to="loc_ifrs-full_CurrentPrepaidExpenses_d4304754-13e8-45bf-9e94-fd1d337622ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_CurrentPrepaymentsRelatedToServiceContracts_66eb4b39-e644-469e-a76c-05af8e6c3eea" xlink:href="bntx-20211231.xsd#bntx_CurrentPrepaymentsRelatedToServiceContracts"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherAssets_714a5748-12b3-4c01-83dc-a855f9060a23" xlink:to="loc_bntx_CurrentPrepaymentsRelatedToServiceContracts_66eb4b39-e644-469e-a76c-05af8e6c3eea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReceivablesFromTaxesOtherThanIncomeTax_4f80cfd5-fb7d-4f90-b4ba-b2cd12dc7b2c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ReceivablesFromTaxesOtherThanIncomeTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherAssets_714a5748-12b3-4c01-83dc-a855f9060a23" xlink:to="loc_ifrs-full_ReceivablesFromTaxesOtherThanIncomeTax_4f80cfd5-fb7d-4f90-b4ba-b2cd12dc7b2c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_OtherCurrentAssetsOther_c379a3d8-18cc-44ed-9423-42e5d87bdcea" xlink:href="bntx-20211231.xsd#bntx_OtherCurrentAssetsOther"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherAssets_714a5748-12b3-4c01-83dc-a855f9060a23" xlink:to="loc_bntx_OtherCurrentAssetsOther_c379a3d8-18cc-44ed-9423-42e5d87bdcea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAdvancesToSuppliers_598480d7-2b32-48db-912e-c286bd250e08" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentAdvancesToSuppliers"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherAssets_714a5748-12b3-4c01-83dc-a855f9060a23" xlink:to="loc_ifrs-full_CurrentAdvancesToSuppliers_598480d7-2b32-48db-912e-c286bd250e08" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/DeferredExpensesSummaryofDeferredExpensesDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#DeferredExpensesSummaryofDeferredExpensesDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/DeferredExpensesSummaryofDeferredExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_bntx_DeferredExpense_9f37d517-1758-4285-9ac8-f4046fa0c343" xlink:href="bntx-20211231.xsd#bntx_DeferredExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_OtherDeferredExpenses_02d4336e-45a5-47e2-ab46-bdef5fee1ed2" xlink:href="bntx-20211231.xsd#bntx_OtherDeferredExpenses"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_DeferredExpense_9f37d517-1758-4285-9ac8-f4046fa0c343" xlink:to="loc_bntx_OtherDeferredExpenses_02d4336e-45a5-47e2-ab46-bdef5fee1ed2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_DeferredTransportationCosts_fc355df7-48d6-43a6-b1a1-849b2875c2a8" xlink:href="bntx-20211231.xsd#bntx_DeferredTransportationCosts"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_DeferredExpense_9f37d517-1758-4285-9ac8-f4046fa0c343" xlink:to="loc_bntx_DeferredTransportationCosts_fc355df7-48d6-43a6-b1a1-849b2875c2a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_DeferredExpensesFromContractManufacturingAndContractResearchOrganizations_ab3225f8-57bb-41a2-b275-ecab2401fbd5" xlink:href="bntx-20211231.xsd#bntx_DeferredExpensesFromContractManufacturingAndContractResearchOrganizations"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_DeferredExpense_9f37d517-1758-4285-9ac8-f4046fa0c343" xlink:to="loc_bntx_DeferredExpensesFromContractManufacturingAndContractResearchOrganizations_ab3225f8-57bb-41a2-b275-ecab2401fbd5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_DeferredRemunerationFromBusinessCombination_bcb88340-7f7e-4c90-a813-283116d3c20a" xlink:href="bntx-20211231.xsd#bntx_DeferredRemunerationFromBusinessCombination"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_DeferredExpense_9f37d517-1758-4285-9ac8-f4046fa0c343" xlink:to="loc_bntx_DeferredRemunerationFromBusinessCombination_bcb88340-7f7e-4c90-a813-283116d3c20a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_DeferredExpensesFromInsuranceContracts_d3d4c2c4-66cd-4e12-8cb5-8b19d635f480" xlink:href="bntx-20211231.xsd#bntx_DeferredExpensesFromInsuranceContracts"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_DeferredExpense_9f37d517-1758-4285-9ac8-f4046fa0c343" xlink:to="loc_bntx_DeferredExpensesFromInsuranceContracts_d3d4c2c4-66cd-4e12-8cb5-8b19d635f480" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/DeferredExpensesSummaryofDeferredExpensesDetails_1" xlink:type="simple" xlink:href="bntx-20211231.xsd#DeferredExpensesSummaryofDeferredExpensesDetails_1"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/DeferredExpensesSummaryofDeferredExpensesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_bntx_DeferredExpense_f41d82c4-5acf-4c3a-88c4-96d2e31dc014" xlink:href="bntx-20211231.xsd#bntx_DeferredExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_DeferredExpenseCurrent_f30b11ca-6f77-4d38-97b3-100e7aa2991c" xlink:href="bntx-20211231.xsd#bntx_DeferredExpenseCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_DeferredExpense_f41d82c4-5acf-4c3a-88c4-96d2e31dc014" xlink:to="loc_bntx_DeferredExpenseCurrent_f30b11ca-6f77-4d38-97b3-100e7aa2991c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_DeferredExpenseNonCurrent_6d63ffe9-37a0-4df2-86bc-1a62cfa2d8ce" xlink:href="bntx-20211231.xsd#bntx_DeferredExpenseNonCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_DeferredExpense_f41d82c4-5acf-4c3a-88c4-96d2e31dc014" xlink:to="loc_bntx_DeferredExpenseNonCurrent_6d63ffe9-37a0-4df2-86bc-1a62cfa2d8ce" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/ShareBasedPaymentsScheduleOfExpenseRecognizedforEmployeeServicesReceivedDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#ShareBasedPaymentsScheduleOfExpenseRecognizedforEmployeeServicesReceivedDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ShareBasedPaymentsScheduleOfExpenseRecognizedforEmployeeServicesReceivedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees_8657b9d8-2891-4aa1-bc0e-31d4bf2836df" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExpenseFromEquitysettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_9eade5a5-44ca-4edb-837c-a0639047c353" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ExpenseFromEquitysettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees_8657b9d8-2891-4aa1-bc0e-31d4bf2836df" xlink:to="loc_ifrs-full_ExpenseFromEquitysettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_9eade5a5-44ca-4edb-837c-a0639047c353" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExpenseFromCashsettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_5c40750d-5179-41bf-a0ef-0765cadc102c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ExpenseFromCashsettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees_8657b9d8-2891-4aa1-bc0e-31d4bf2836df" xlink:to="loc_ifrs-full_ExpenseFromCashsettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_5c40750d-5179-41bf-a0ef-0765cadc102c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/OtherLiabilitiesSummaryofOtherLiabilitiesDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#OtherLiabilitiesSummaryofOtherLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/OtherLiabilitiesSummaryofOtherLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherLiabilities_f0c24300-9762-41b5-93f2-a30f51a63f0f" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_LiabilitiesForEmployeeBenefits_de950f64-56e7-43c1-9c71-6451df30b066" xlink:href="bntx-20211231.xsd#bntx_LiabilitiesForEmployeeBenefits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherLiabilities_f0c24300-9762-41b5-93f2-a30f51a63f0f" xlink:to="loc_bntx_LiabilitiesForEmployeeBenefits_de950f64-56e7-43c1-9c71-6451df30b066" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_OtherLiabilitiesOther_ca586c4c-fa96-4031-9291-dfe5dbe2af16" xlink:href="bntx-20211231.xsd#bntx_OtherLiabilitiesOther"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherLiabilities_f0c24300-9762-41b5-93f2-a30f51a63f0f" xlink:to="loc_bntx_OtherLiabilitiesOther_ca586c4c-fa96-4031-9291-dfe5dbe2af16" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/OtherLiabilitiesSummaryofOtherLiabilitiesDetails_1" xlink:type="simple" xlink:href="bntx-20211231.xsd#OtherLiabilitiesSummaryofOtherLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/OtherLiabilitiesSummaryofOtherLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherLiabilities_a975c6de-198d-43c9-99b9-c2f847edceb4" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentLiabilities_44e6268c-63e7-44bf-974f-16127e33bee2" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherCurrentLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherLiabilities_a975c6de-198d-43c9-99b9-c2f847edceb4" xlink:to="loc_ifrs-full_OtherCurrentLiabilities_44e6268c-63e7-44bf-974f-16127e33bee2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentLiabilities_d9e6cf5a-7c5e-4914-bc41-8af90d56ec0f" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherNoncurrentLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherLiabilities_a975c6de-198d-43c9-99b9-c2f847edceb4" xlink:to="loc_ifrs-full_OtherNoncurrentLiabilities_d9e6cf5a-7c5e-4914-bc41-8af90d56ec0f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/LeasesSummaryofLeaseLiabilityIncludedinInterestBearingLoansandBorrowingsDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#LeasesSummaryofLeaseLiabilityIncludedinInterestBearingLoansandBorrowingsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/LeasesSummaryofLeaseLiabilityIncludedinInterestBearingLoansandBorrowingsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LeaseLiabilities_6b88cd66-b2fc-42fb-8238-95ec9a96a9df" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_LeaseLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLeaseLiabilities_57477941-e8b7-459c-9879-4290b385baa2" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentLeaseLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_LeaseLiabilities_6b88cd66-b2fc-42fb-8238-95ec9a96a9df" xlink:to="loc_ifrs-full_CurrentLeaseLiabilities_57477941-e8b7-459c-9879-4290b385baa2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLeaseLiabilities_c9236262-85aa-48a0-83ba-3e0764011b97" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentLeaseLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_LeaseLiabilities_6b88cd66-b2fc-42fb-8238-95ec9a96a9df" xlink:to="loc_ifrs-full_NoncurrentLeaseLiabilities_c9236262-85aa-48a0-83ba-3e0764011b97" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/LeasessummaryofAmountsRecognizedinConsolidatedStatementofOperationsDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#LeasessummaryofAmountsRecognizedinConsolidatedStatementofOperationsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/LeasessummaryofAmountsRecognizedinConsolidatedStatementofOperationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_bntx_LeaseExpensesRecognizedInProfitOrLoss_6219a391-9b79-4392-8a0d-11db94a7b973" xlink:href="bntx-20211231.xsd#bntx_LeaseExpensesRecognizedInProfitOrLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExpenseRelatingToShorttermLeasesForWhichRecognitionExemptionHasBeenUsed_3d4ba3f9-6525-49e6-a349-0e4bb95f79bd" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ExpenseRelatingToShorttermLeasesForWhichRecognitionExemptionHasBeenUsed"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_LeaseExpensesRecognizedInProfitOrLoss_6219a391-9b79-4392-8a0d-11db94a7b973" xlink:to="loc_ifrs-full_ExpenseRelatingToShorttermLeasesForWhichRecognitionExemptionHasBeenUsed_3d4ba3f9-6525-49e6-a349-0e4bb95f79bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DepreciationRightofuseAssets_b0b7dcd9-3fd0-4071-ada3-d5e167c40ea0" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DepreciationRightofuseAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_LeaseExpensesRecognizedInProfitOrLoss_6219a391-9b79-4392-8a0d-11db94a7b973" xlink:to="loc_ifrs-full_DepreciationRightofuseAssets_b0b7dcd9-3fd0-4071-ada3-d5e167c40ea0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExpenseRelatingToLeasesOfLowvalueAssetsForWhichRecognitionExemptionHasBeenUsed_4808a66f-ff38-4aff-a463-a6aa17b6a171" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ExpenseRelatingToLeasesOfLowvalueAssetsForWhichRecognitionExemptionHasBeenUsed"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_LeaseExpensesRecognizedInProfitOrLoss_6219a391-9b79-4392-8a0d-11db94a7b973" xlink:to="loc_ifrs-full_ExpenseRelatingToLeasesOfLowvalueAssetsForWhichRecognitionExemptionHasBeenUsed_4808a66f-ff38-4aff-a463-a6aa17b6a171" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestExpenseOnLeaseLiabilities_58d31666-ba8c-4e28-9eda-92d81bbd7734" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_InterestExpenseOnLeaseLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_LeaseExpensesRecognizedInProfitOrLoss_6219a391-9b79-4392-8a0d-11db94a7b973" xlink:to="loc_ifrs-full_InterestExpenseOnLeaseLiabilities_58d31666-ba8c-4e28-9eda-92d81bbd7734" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/RelatedPartyDisclosuresSummaryofCompensationofKeyManagementPersonnelDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#RelatedPartyDisclosuresSummaryofCompensationofKeyManagementPersonnelDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/RelatedPartyDisclosuresSummaryofCompensationofKeyManagementPersonnelDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_KeyManagementPersonnelCompensation_c9d66b93-e8c6-4519-851e-8631450ecdc5" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_KeyManagementPersonnelCompensation"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_KeyManagementPersonnelCompensationShortTermEmployeeBenefitsSecondInstallment_caae5ce7-0aaf-4061-8673-3f7d087a0b65" xlink:href="bntx-20211231.xsd#bntx_KeyManagementPersonnelCompensationShortTermEmployeeBenefitsSecondInstallment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_c9d66b93-e8c6-4519-851e-8631450ecdc5" xlink:to="loc_bntx_KeyManagementPersonnelCompensationShortTermEmployeeBenefitsSecondInstallment_caae5ce7-0aaf-4061-8673-3f7d087a0b65" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_KeyManagementPersonnelCompensationShorttermEmployeeBenefits_35452bf6-1253-4571-b400-664d2d82a9df" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_KeyManagementPersonnelCompensationShorttermEmployeeBenefits"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_c9d66b93-e8c6-4519-851e-8631450ecdc5" xlink:to="loc_ifrs-full_KeyManagementPersonnelCompensationShorttermEmployeeBenefits_35452bf6-1253-4571-b400-664d2d82a9df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_KeyManagementPersonnelCompensationSharebasedPayment_058b3099-05ef-43fb-a92e-3330b9d19af1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_KeyManagementPersonnelCompensationSharebasedPayment"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_c9d66b93-e8c6-4519-851e-8631450ecdc5" xlink:to="loc_ifrs-full_KeyManagementPersonnelCompensationSharebasedPayment_058b3099-05ef-43fb-a92e-3330b9d19af1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_KeyManagementPersonnelCompensationFixedCompensation_60734487-cecb-43c3-850e-e8791dcd9893" xlink:href="bntx-20211231.xsd#bntx_KeyManagementPersonnelCompensationFixedCompensation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_c9d66b93-e8c6-4519-851e-8631450ecdc5" xlink:to="loc_bntx_KeyManagementPersonnelCompensationFixedCompensation_60734487-cecb-43c3-850e-e8791dcd9893" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_KeyManagementPersonnelCompensationFringeBenefits_bee13629-529f-41e2-acc3-678420e4d372" xlink:href="bntx-20211231.xsd#bntx_KeyManagementPersonnelCompensationFringeBenefits"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_c9d66b93-e8c6-4519-851e-8631450ecdc5" xlink:to="loc_bntx_KeyManagementPersonnelCompensationFringeBenefits_bee13629-529f-41e2-acc3-678420e4d372" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_KeyManagementPersonnelCompensationOtherPerformanceRelatedVariableCompensation_5124125b-6f2a-48da-a247-a885b3ebf58b" xlink:href="bntx-20211231.xsd#bntx_KeyManagementPersonnelCompensationOtherPerformanceRelatedVariableCompensation"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_c9d66b93-e8c6-4519-851e-8631450ecdc5" xlink:to="loc_bntx_KeyManagementPersonnelCompensationOtherPerformanceRelatedVariableCompensation_5124125b-6f2a-48da-a247-a885b3ebf58b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/RelatedPartyDisclosuresSummaryofAggregateValueofTransactionsRelatedtoKeyManagementPersonnelDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#RelatedPartyDisclosuresSummaryofAggregateValueofTransactionsRelatedtoKeyManagementPersonnelDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/RelatedPartyDisclosuresSummaryofAggregateValueofTransactionsRelatedtoKeyManagementPersonnelDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_bntx_GoodsAndServicesFromRelatedPartyTransactions_cc92f09c-bbb4-43e8-aa48-f0f5180d3f2c" xlink:href="bntx-20211231.xsd#bntx_GoodsAndServicesFromRelatedPartyTransactions"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ConsultingServicesAndPatentAssignment_5af60be1-20b6-4353-bcbd-a3a1d014fc6a" xlink:href="bntx-20211231.xsd#bntx_ConsultingServicesAndPatentAssignment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_GoodsAndServicesFromRelatedPartyTransactions_cc92f09c-bbb4-43e8-aa48-f0f5180d3f2c" xlink:to="loc_bntx_ConsultingServicesAndPatentAssignment_5af60be1-20b6-4353-bcbd-a3a1d014fc6a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_PurchasesOfGoodsAndServiceRelatedPartyTransactions_989c8c5a-a449-4829-8b4b-f6581ab812fb" xlink:href="bntx-20211231.xsd#bntx_PurchasesOfGoodsAndServiceRelatedPartyTransactions"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_GoodsAndServicesFromRelatedPartyTransactions_cc92f09c-bbb4-43e8-aa48-f0f5180d3f2c" xlink:to="loc_bntx_PurchasesOfGoodsAndServiceRelatedPartyTransactions_989c8c5a-a449-4829-8b4b-f6581ab812fb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/RelatedPartyDisclosuresSummaryofTransactionsBetweenRelatedPartiesAmountDetails" xlink:type="simple" xlink:href="bntx-20211231.xsd#RelatedPartyDisclosuresSummaryofTransactionsBetweenRelatedPartiesAmountDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/RelatedPartyDisclosuresSummaryofTransactionsBetweenRelatedPartiesAmountDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_bntx_PurchasesFromRelatedPartyTransactions_fe9fa1a6-8170-49de-b4ca-d6c730a49ee6" xlink:href="bntx-20211231.xsd#bntx_PurchasesFromRelatedPartyTransactions"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_PurchasesOfGoodsAndServiceRelatedPartyTransactions_570f3023-a553-4e4e-b010-df2f6c645092" xlink:href="bntx-20211231.xsd#bntx_PurchasesOfGoodsAndServiceRelatedPartyTransactions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_PurchasesFromRelatedPartyTransactions_fe9fa1a6-8170-49de-b4ca-d6c730a49ee6" xlink:to="loc_bntx_PurchasesOfGoodsAndServiceRelatedPartyTransactions_570f3023-a553-4e4e-b010-df2f6c645092" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchasesOfPropertyAndOtherAssetsRelatedPartyTransactions_a41f9c49-4b62-486c-9b4b-4970bfdc3c02" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PurchasesOfPropertyAndOtherAssetsRelatedPartyTransactions"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_PurchasesFromRelatedPartyTransactions_fe9fa1a6-8170-49de-b4ca-d6c730a49ee6" xlink:to="loc_ifrs-full_PurchasesOfPropertyAndOtherAssetsRelatedPartyTransactions_a41f9c49-4b62-486c-9b4b-4970bfdc3c02" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
