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<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2020-03-31T16:38:31.0057288+00:00 -->
<!-- Version            : 5.0.1.369 -->
<!-- Package ID         : 1445d6cf08e547959294e9e88ffa1b70 -->
<!-- Copyright (c) 2020 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="bntx_DisclosureOfGoodwillAcquiredInRespectiveBusinessCombinationsExplanatory" name="DisclosureOfGoodwillAcquiredInRespectiveBusinessCombinationsExplanatory" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_DisclosureOfFinancialLiabilitiesInterestBearingLoansAndBorrowingsExplanatory" name="DisclosureOfFinancialLiabilitiesInterestBearingLoansAndBorrowingsExplanatory" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_DisclosureOfForeignCurrencyRiskExplanatory" name="DisclosureOfForeignCurrencyRiskExplanatory" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_DisclosureOfClassesOfInventoriesExplanatory" name="DisclosureOfClassesOfInventoriesExplanatory" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_DisclosureOfDetailedInformationAboutTradeAndOtherReceivablesExplanatory" name="DisclosureOfDetailedInformationAboutTradeAndOtherReceivablesExplanatory" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
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  <xsd:element id="bntx_EmployeeStockOwnershipPlanMember" name="EmployeeStockOwnershipPlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_ShareAppreciationRightMember" name="ShareAppreciationRightMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_DisclosureOfDetailedInformationAboutOtherLiabilitiesExplanatory" name="DisclosureOfDetailedInformationAboutOtherLiabilitiesExplanatory" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_DisclosureOfDetailedInformationAboutLeaseLiabilitiesExplanatory" name="DisclosureOfDetailedInformationAboutLeaseLiabilitiesExplanatory" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_DisclosureOfDetailedInformationAboutLeaseExpenseRecognizedInstatementOfOperationsExplanatory" name="DisclosureOfDetailedInformationAboutLeaseExpenseRecognizedInstatementOfOperationsExplanatory" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_EquipmentToolsAndInstallationsMember" name="EquipmentToolsAndInstallationsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_UsefulLifeMeasuredAsPeriodOfTimeRightOfUseAssets" name="UsefulLifeMeasuredAsPeriodOfTimeRightOfUseAssets" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_IntellectualPropertyRightsMember" name="IntellectualPropertyRightsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_CollaborationAndLicenseAgreementMember" name="CollaborationAndLicenseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <xsd:element id="bntx_PfizerIncMember" name="PfizerIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_SanofiSAMember" name="SanofiSAMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <xsd:element id="bntx_EliLillyAndCompanyMember" name="EliLillyAndCompanyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_PaymentsFromContractsWithCustomersReceivedThroughCurrentReportingPeriod" name="PaymentsFromContractsWithCustomersReceivedThroughCurrentReportingPeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
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  <xsd:element id="bntx_CellscriptSublicenseMember" name="CellscriptSublicenseMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_BillAndHoldTransactionMember" name="BillAndHoldTransactionMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <xsd:element id="bntx_SublicenseAgreementDate" name="SublicenseAgreementDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
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  <xsd:element id="bntx_TradeReceivableMaturityPeriod" name="TradeReceivableMaturityPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_UpfrontFeesOrUnconditionalRightOfConsideration" name="UpfrontFeesOrUnconditionalRightOfConsideration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="bntx_DeferredRevenueRecognizedIncludedContractLiabilities" name="DeferredRevenueRecognizedIncludedContractLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="bntx_UnsatisfiedOrPartiallyUnsatisfiedMember" name="UnsatisfiedOrPartiallyUnsatisfiedMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_ConsiderationFromContractsWithCustomersIsNotIncludedInDisclosureOfTransactionPriceAllocatedToRemainingPerformanceObligations" name="ConsiderationFromContractsWithCustomersIsNotIncludedInDisclosureOfTransactionPriceAllocatedToRemainingPerformanceObligations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
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  <xsd:element id="bntx_BioNTechDeliveryTechnologiesGmbHMember" name="BioNTechDeliveryTechnologiesGmbHMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <xsd:element id="bntx_BioNTechSmallMoleculesGmbHMember" name="BioNTechSmallMoleculesGmbHMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_BioNTechIVACGmbHMember" name="BioNTechIVACGmbHMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_BioNTechAustriaBeteiligungenGmbHMember" name="BioNTechAustriaBeteiligungenGmbHMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_BioNTechInnovativeManufacturingServicesGmbHMember" name="BioNTechInnovativeManufacturingServicesGmbHMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <xsd:element id="bntx_BioNTechResearchAndDevelopmentIncMember" name="BioNTechResearchAndDevelopmentIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_BioNTechCellAndGeneTherapiesGmbHMember" name="BioNTechCellAndGeneTherapiesGmbHMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_BioNTechRealEstateHoldingGmbHMember" name="BioNTechRealEstateHoldingGmbHMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_BioNTechRealEstateVerwaltungsGmbHMember" name="BioNTechRealEstateVerwaltungsGmbHMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_BioNTechRealEstateGmbHAndCoKGMember" name="BioNTechRealEstateGmbHAndCoKGMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <xsd:element id="bntx_ATImpfGmbHMember" name="ATImpfGmbHMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_ATHOSKGMember" name="ATHOSKGMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <xsd:element id="bntx_MedineGmbHMember" name="MedineGmbHMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_MABDiscoveryGmbHMember" name="MABDiscoveryGmbHMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_TechnologyPlatformBusinessSegmentMember" name="TechnologyPlatformBusinessSegmentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_NetCashAcquired" name="NetCashAcquired" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="bntx_PaymentsToAcquireBusiness" name="PaymentsToAcquireBusiness" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="bntx_DisclosureOfIncomeAndExpensesLineItems" name="DisclosureOfIncomeAndExpensesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_DisclosureOfIncomeAndExpensesTable" name="DisclosureOfIncomeAndExpensesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_IncomeAndExpensesByNatureAxis" name="IncomeAndExpensesByNatureAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <xsd:element id="bntx_WagesBenefitsAndSocialSecurityExpenseMember" name="WagesBenefitsAndSocialSecurityExpenseMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_LaboratorySuppliesMember" name="LaboratorySuppliesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_PurchasedServicesMember" name="PurchasedServicesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <xsd:element id="bntx_LeaseAndLeaseRelatedCostMember" name="LeaseAndLeaseRelatedCostMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_ITCostsMember" name="ITCostsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_TravelCostsMember" name="TravelCostsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_TransportCostsMember" name="TransportCostsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_JobAdvertisementExpensesMember" name="JobAdvertisementExpensesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_InsurancePremiumsMember" name="InsurancePremiumsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_GovernmentGrantsMember" name="GovernmentGrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_FinancialInstrumentsMeasuredAtAmortisedCost" name="FinancialInstrumentsMeasuredAtAmortisedCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_GovernmentGrantsExemptedFromTaxes" name="GovernmentGrantsExemptedFromTaxes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="bntx_AddBackForTradeTaxPurposes" name="AddBackForTradeTaxPurposes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_NonRecognitionOfTaxEffectOnShareBasedPaymentExpenses" name="NonRecognitionOfTaxEffectOnShareBasedPaymentExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_TaxEffectiveEquityTransactionCosts" name="TaxEffectiveEquityTransactionCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_TaxEffectOfNonrecognitionOfDeferredTaxesOnTaxLossesAndTemporaryDifferences" name="TaxEffectOfNonrecognitionOfDeferredTaxesOnTaxLossesAndTemporaryDifferences" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_TaxEffectInDeviationValuationAllowanceFromChangeInTaxRate" name="TaxEffectInDeviationValuationAllowanceFromChangeInTaxRate" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_IncomeTaxExpenseExcludingPropertyTax" name="IncomeTaxExpenseExcludingPropertyTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
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  <xsd:element id="bntx_FixedAssetsMember" name="FixedAssetsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_LeasesMember" name="LeasesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_InventoryMember" name="InventoryMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_ContractLiabilitiesMember" name="ContractLiabilitiesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_ProvisionsMember" name="ProvisionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_OtherDeferredTaxesMember" name="OtherDeferredTaxesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_AccumulatedTaxLossesInCorporateTax" name="AccumulatedTaxLossesInCorporateTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="bntx_AccumulatedTaxLossesInTradeTax" name="AccumulatedTaxLossesInTradeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="bntx_DeferredTaxAssetsForUnusedTaxLossesRecognized" name="DeferredTaxAssetsForUnusedTaxLossesRecognized" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="bntx_SharesIssuedDuringPeriodStockSplit" name="SharesIssuedDuringPeriodStockSplit" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_ReclassificationsPropertyPlantAndEquipment" name="ReclassificationsPropertyPlantAndEquipment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_ConstructionInProgressAndAdvancePaymentsMember" name="ConstructionInProgressAndAdvancePaymentsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_AccumulatedDepreciationAmortisationAndImpairment" name="AccumulatedDepreciationAmortisationAndImpairment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_ConcessionsLicensesAndSimilarRightsMember" name="ConcessionsLicensesAndSimilarRightsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_AdvancePaymentsMember" name="AdvancePaymentsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_MABDiscoveryMember" name="MABDiscoveryMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_JPTPeptideTechnologiesMember" name="JPTPeptideTechnologiesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_ReBOOSTMember" name="ReBOOSTMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_OtherFinancialAssetsAndReceivablesMember" name="OtherFinancialAssetsAndReceivablesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_TwoPointOneFivePercentageSecuredBankLoanMember" name="TwoPointOneFivePercentageSecuredBankLoanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_TwoPointZeroEightPercentageSecuredBankLoanMember" name="TwoPointZeroEightPercentageSecuredBankLoanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_TradePayablesMember" name="TradePayablesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_OtherFinancialLiabilitiesMember" name="OtherFinancialLiabilitiesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_FinancialLiabilitiesMaturityDate" name="FinancialLiabilitiesMaturityDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_LoanRepayableQuarterlyInstallment" name="LoanRepayableQuarterlyInstallment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_TwoPointOneFivePercentageSecuredLoanMember" name="TwoPointOneFivePercentageSecuredLoanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_TwoPointZeroEightPercentageBankLoanMember" name="TwoPointZeroEightPercentageBankLoanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_CashAndCashEquivalent" name="CashAndCashEquivalent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_DisclosureOfCashAndCashEquivalentsLineItems" name="DisclosureOfCashAndCashEquivalentsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_DisclosureOfCashAndCashEquivalentsTable" name="DisclosureOfCashAndCashEquivalentsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_USDBankAccountsMember" name="USDBankAccountsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_DisclosureOfEffectOfChangesInForeignExchangeRatesAbstract" name="DisclosureOfEffectOfChangesInForeignExchangeRatesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_DisclosureOfEffectOfChangesInForeignExchangeRatesLineItems" name="DisclosureOfEffectOfChangesInForeignExchangeRatesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_DisclosureOfEffectOfChangesInForeignExchangeRatesTable" name="DisclosureOfEffectOfChangesInForeignExchangeRatesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_PositiveFivePercentageChangeInForeignExchangeRateMember" name="PositiveFivePercentageChangeInForeignExchangeRateMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_NegativeFivePercentageChangeInForeignExchangeRateMember" name="NegativeFivePercentageChangeInForeignExchangeRateMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_ForeignCurrencyChangesEffectOnLossBeforeTax" name="ForeignCurrencyChangesEffectOnLossBeforeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_ForeignCurrencyChangesEffectOnPretaxEquity" name="ForeignCurrencyChangesEffectOnPretaxEquity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_CurrentObligationsUnderLeaseContractsMember" name="CurrentObligationsUnderLeaseContractsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_NoncurrentObligationsUnderLeaseContractsMember" name="NoncurrentObligationsUnderLeaseContractsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_InterestBearingLoansAndBorrowingsMember" name="InterestBearingLoansAndBorrowingsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_TradeAndOtherReceivablesLineItems" name="TradeAndOtherReceivablesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_TradeAndOtherReceivablesTable" name="TradeAndOtherReceivablesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_OtherCurrentAssetsOther" name="OtherCurrentAssetsOther" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_ReceivablesFromInterest" name="ReceivablesFromInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="bntx_ReceivablesFromWithholdingTaxes" name="ReceivablesFromWithholdingTaxes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_BillAndMeLindaGatesFoundationMember" name="BillAndMeLindaGatesFoundationMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_OrdinarySharesSeriesBMember" name="OrdinarySharesSeriesBMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_InitialPublicOfferingMember" name="InitialPublicOfferingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_SeriesAFinancingRoundMember" name="SeriesAFinancingRoundMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_SettlingShareBasedPaymentPlanMember" name="SettlingShareBasedPaymentPlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_CashInvestment" name="CashInvestment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_SharesIssuedPricePerShare1" name="SharesIssuedPricePerShare1" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="bntx_IncreaseInCapitalReserve" name="IncreaseInCapitalReserve" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="bntx_RemainingNoncontrollingInterestsAcquiredPercentage" name="RemainingNoncontrollingInterestsAcquiredPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_DerecognitionOfNonControllingInterest" name="DerecognitionOfNonControllingInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_DecreaseInCapitalReserve" name="DecreaseInCapitalReserve" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_IncreaseInIssuedCapital" name="IncreaseInIssuedCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="bntx_ExercisePriceCurrencyTranslationOfPublicOfferingPricePerShare" name="ExercisePriceCurrencyTranslationOfPublicOfferingPricePerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_OptionVestingPeriod" name="OptionVestingPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_PercentageOfIncreaseInExercisePrice" name="PercentageOfIncreaseInExercisePrice" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_ThresholdAmountOfDividendByNumberOfSharesOutstandingImmediatelyFollowingInitialPublicOffering" name="ThresholdAmountOfDividendByNumberOfSharesOutstandingImmediatelyFollowingInitialPublicOffering" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_PercentageOfTargetSharePriceApplicableForPriorTwelveMonth" name="PercentageOfTargetSharePriceApplicableForPriorTwelveMonth" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_OptionExercisablePeriod" name="OptionExercisablePeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_NatureOfExpensesAxis" name="NatureOfExpensesAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_NatureOfExpensesMember" name="NatureOfExpensesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_ResearchAndDevelopmentExpensesMember" name="ResearchAndDevelopmentExpensesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_CostOfSales1Member" name="CostOfSales1Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_SalesAndMarketingExpensesMember" name="SalesAndMarketingExpensesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_GeneralAndAdministrativeExpensesMember" name="GeneralAndAdministrativeExpensesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_NumberOfShareOptionsCancelledOrModifiedInSharebasedPaymentArrangement" name="NumberOfShareOptionsCancelledOrModifiedInSharebasedPaymentArrangement" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_NumberOfOrdinarySharesUnderlyingOptionsOutstanding" name="NumberOfOrdinarySharesUnderlyingOptionsOutstanding" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="bntx_NumberOfOrdinarySharesUnderlyingOptionsGrantedInSharebasedPaymentArrangement" name="NumberOfOrdinarySharesUnderlyingOptionsGrantedInSharebasedPaymentArrangement" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_NumberOfOrdinarySharesUnderlyingOptionsForfeitedInSharebasedPaymentArrangement" name="NumberOfOrdinarySharesUnderlyingOptionsForfeitedInSharebasedPaymentArrangement" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_WeightedAverageCostOfCapitalAsPercentageShareOptionsGranted" name="WeightedAverageCostOfCapitalAsPercentageShareOptionsGranted" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_TaxRateShareOptionsGranted" name="TaxRateShareOptionsGranted" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_DebtFreeNetWorkingCapitalShareOptionsGranted" name="DebtFreeNetWorkingCapitalShareOptionsGranted" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_LongtermGrowthRateShareOptionsGranted" name="LongtermGrowthRateShareOptionsGranted" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_PaymentsRelatedToWithholdingTaxForSharebasedPaymentTransactions" name="PaymentsRelatedToWithholdingTaxForSharebasedPaymentTransactions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="bntx_CurrentLiabilitiesForEmployeesBenefits" name="CurrentLiabilitiesForEmployeesBenefits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="bntx_OtherLiabilitiesOther" name="OtherLiabilitiesOther" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="bntx_LeaseExpensesRecognizedInProfitOrLoss" name="LeaseExpensesRecognizedInProfitOrLoss" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_NumberOfBusinessUnits" name="NumberOfBusinessUnits" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_NumberOfOperationSegments" name="NumberOfOperationSegments" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_NumberOfOperatingSegmentsInAccordanceWithIFRS8" name="NumberOfOperatingSegmentsInAccordanceWithIFRS8" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_BusinessUnitBiontechMember" name="BusinessUnitBiontechMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_AdjustmentsMember" name="AdjustmentsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_ClinicalBusinessUnitMember" name="ClinicalBusinessUnitMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_TechnologyPlatformBusinessUnitMember" name="TechnologyPlatformBusinessUnitMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_ManufacturingBusinessUnitMember" name="ManufacturingBusinessUnitMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_BusinessServiceBusinessUnitMember" name="BusinessServiceBusinessUnitMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_ProductSalesAndExternalServicesBusinessUnitMember" name="ProductSalesAndExternalServicesBusinessUnitMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_CollaborationAndLicenseAgreementsMember" name="CollaborationAndLicenseAgreementsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_CofounderAndChiefExecutiveOfficerMember" name="CofounderAndChiefExecutiveOfficerMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_ConsultingServicesAndPatentAssignment" name="ConsultingServicesAndPatentAssignment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_PurchasesOfGoodsAndServiceRelatedPartyTransactions" name="PurchasesOfGoodsAndServiceRelatedPartyTransactions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_GoodsAndServicesFromRelatedPartyTransactions" name="GoodsAndServicesFromRelatedPartyTransactions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_TRONMember" name="TRONMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_PurchasesFromRelatedPartyTransactions" name="PurchasesFromRelatedPartyTransactions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="bntx_DisclosureOfEventsAfterReportingPeriodLineItems" name="DisclosureOfEventsAfterReportingPeriodLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_DisclosureOfEventsAfterReportingPeriodTable" name="DisclosureOfEventsAfterReportingPeriodTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_BioNTechDeliveryTechnologiesMember" name="BioNTechDeliveryTechnologiesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_LipoCalyxMember" name="LipoCalyxMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_NeonTherapeuticsIncMember" name="NeonTherapeuticsIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_ResearchAndDevelopmentEffortMember" name="ResearchAndDevelopmentEffortMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_FosunPharmaMember" name="FosunPharmaMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="bntx_AmericanDepositorySharesReceivedUponConversion" name="AmericanDepositorySharesReceivedUponConversion" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_StockTransactionValuedAmount" name="StockTransactionValuedAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="bntx_ClosingPriceOfAmericanDepositoryShares" name="ClosingPriceOfAmericanDepositoryShares" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="bntx_UpfrontPotentialFutureInvestmentAndMilestonePayments" name="UpfrontPotentialFutureInvestmentAndMilestonePayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
</xsd:schema>
